Proteinuria Changes in Five Stages of Diabetic Nephropathy
Diabetic Nephropathy is a very common complication of Diabetes. And microalbumin is the earliest symptom indicating the kidney damage. According to proteinuria, Diabetic Nephropathy can be divided into five stages. Now Let’s have a look.
Stage 1: The kidney volume can increase by 25% when taking B ultrasound. The GFR can rise, more than 120ml/min or even 150ml/min, whose level is parallel with the blood sugar. In the renal biopsy, there isn’t abnormality, and the blood pressure is not high. Some symptoms of the early diabetes can be seen, but may recover to the normal state in several weeks to months after controlling the blood sugar strictly and receiving insulin treatment.
Stage 2: When resting, the amount of proteinuria doesn’t increase, however, after sports, the proteinuria increase. For example treadmill can drive the heart rate to a level of 75% of the maximum heart rate of peers. The GFR level can approximate the normal level. If the GFR is still high, it warns of the occurrence of high-risk Diabetes Nephropathy. This stage can be reversible, in which the BP is not high, and after the renal biopsy, the thickness of basement membrane and the multiplication of matrix in the mesangial area can be seen.
Stage 3: We can call it early-stage Diabetic Nephropathy. The proteinuria after sports can turn into continuous proteinuria rise, which can reach to a level of 20-200 mcg/min, the GFR is relatively normal. In the latter stage, the BP will rise slightly. If not treated positively, more than 90% patients can develop to apparent Diabetes Nephropathy.
Stage 4: About 40% of patients with Type 1 Diabetes develop into this stage. The amount of urine protein increases (>0.5g/24h), and most patients have high blood pressure. If the blood pressure isn’t controlled effectively, the GFR can deteriorate at a speed of about 1-1.22ml month/min, and the patient may develop to end Renal Failure within 5-8 years. The renal biopsy can indicate glomerular sclerosis. In this stage, although strict treatments are received, the disease is still irreversible.
Stage 5: The end stage Diabetic Nephropathy. The GFR level can decrease under 10ml/min, the urea and creatinine can rise and the edema and hypertension become more serious. In this stage, it is often accompanied with retina lesion, diabetic nervous lesion.
Generally speaking, patients with Diabetic Nephropathy take dialysis earlier than patients with other kinds of kidney diseases. You can leave us a message, if you would like to know about Diabetic Nephropathy or other complications.
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