Chronic Allograft Nephropathy
Focal Segmental Glomerulosclerosis(FSGS) shows that part of glomeruli or part of capillary loops of glomeruli has pathological changes. Pulp side glomerular is the part influenced first. Obvious lesion of tubulointerstitial appears at the early stage, proteinuria and Nephrotic Syndrome are the obvious clinical symptoms. Its reaction to all kinds of treatments is not good, it is a chronic progressive process and finally develops into Renal Failure.
FSGS is a kind of disease that the glomeruli has been damaged. Maybe people don't know what kind of disease FSGS is exactly, here we will take a simple example: there is a box, and it has many apples in it. Here the box stands for your kidney, and these appears are your glomerulis. FSGS means that some of the apples have been gone bad, but not totally bad, the degree is not that severe. In other words, for every apple that goes bad, a part of it has been bad, while the remaining part still keeps good.
If we take no care of the bad apple, there is no doubt the area that goes bad will become bigger and bigger till the whole apple totally become bad. So, if FSGS can not be controlled well, the whole glomeruli will be sclerotic. And if one apple has been totally bad, it will cause the good apples begin to become bad and the ones which are partly bad become more and more severe. Then the final result will be the whole box of apples get completely bad, all the glomerulis get sclerotic and the kidneys stop working.
FSGS affects both adults and children. Men and boys are affected slightly more often than women and girls, and it also occurs more often in African Americans.
The causes of FSGS include inherited genetic problems, heroin use, HIV, reflux nephropathy, sickle cell disease, obesity and so on.