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The Main Symptoms Of Diabetic Nephropathy In Clinic

2018-09-12 11:19

To most diabetic patients they must know more information about the diabetic nephropathy that can help them get more benefit in treatment and daily life care.As a kidney doctor i will share you the following information :

Clinical manifestations of diabetic nephropathy

1. Glomerular hyperfiltration and renal hypertrophy stage

This initial change is consistent with the level of hyperglycemia and can be partially relieved after blood glucose control. There was no pathological injury in this period.

2. persistent large amount of albumin urinary

GFR is higher than normal. Renal pathology showed GBM thickening, mesangial matrix increasing, urinary albumin excretion rate ( UAE ) increasing ( > 20μ g / min ) after exercise.Return to normal after rest. If the blood sugar can be well controlled in this phase, the patient can stay stable in this phase for a long time.

3. Early diabetic nephropathy, also known as ” continuous microalbuminuria period

GFR began to drop to normal. Renal pathology showed glomerular nodular lesions and arteriolar hyaline changes. UAE continued to rise to 20 ~ 200μ g / min, resulting in microalbuminuria. The patient’s blood pressure increased in this period. Treatment with ACEI or ARB drugs can reduce urinary albumin excretion and delay the progression of kidney disease.

4. Clinical diabetic nephropathy

The typical K – W nodule appeared pathologically. Persistent massive albuminuria ( UAE > 200μ g / min ) or albuminuria greater than 500 mg / d, about 30 % of patients may develop Nephrotic syndrome.GFR continues to decline. The characteristic of this period is that urine protein does not decrease with the decrease of GFR. Once a patient enters phase IV, the condition often develops progressively. If it is not controlled, the GFR will decrease by an average of 1 ml / min per month.

5. End – stage renal failure

GFR<10ml/min。 The amount of urine protein decreased due to glomerular sclerosis. uremia has obvious symptoms and needs dialysis treatment.

The above stages are mainly based on type 1 diabetic nephropathy, while type 2 diabetic nephropathy is not obvious.

From the comments about the symptoms of diabetic nephropathy, i think many patients are more worrying about that ,as a kidney doctor i think if you can accept the reasonable treatment in time your condition can be improved gradually,if you want to promote your kidney condition please contact us through the following message:

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Tag: Diabetic Nephropathy Glomerular Hyperfiltration Albumin urinary Continuous microalbuminuria period

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