Chronic Allograft Nephropathy
Lupus Nephritis forms as a result of SLE (systemic lupus erythematosus) attacking one's kidneys. How does the disease occur? Since SLE or lupus is an autoimmune disease, meaning one's own immune system targets one's own tissues or organs. In cases of lupus nephritis, lupus strikes kidneys.
The disease usually affects people between their ages of 20 to 40. It is estimated that no less than 40% of people developing lupus would develop complications involved in kidneys and requires medical treatment. Some even don't have a clue about their kidney problems before diagnosed with SLE. Except for kidney involvement, many other parts of the body are implicated too; for instance, joint, blood, skin, heart, lung, eyes and so on.
Few signs or symptoms appear when one suffers from Lupus Nephritis, so further lab test or exams are required to confirm the disease. According to WHO classification system for LN, five classes are divided:
Kidney function is still normal in Class one,
Mild form of LN would appear in Class two. In this class, hormonotherapy works well.
Focal proliferative nephritis develops as an early stage of advanced disease. In this class, hormonotherapy doesn't work as well as before, sometimes, high dose of medications could deal with the kidney disease.
In class 4, kidney function begins to decline progressively over time. hormonotherapy along with immunosuppressant would be used jointly.
Membranous nephropathy shows up in class five; additionally, massive loss of protein in urine and edema present accordingly.
No known prevention could help us stay away from Lupus Nephritis. So its prognosis or outlook all depends on how serious your kidneys are damaged. Some of them recover very soon, while others develop Chronic Renal Failure over time. Due to the disease is induced by primary one—SLE, the control of primary disease matters and directly decides the prognosis of Lupus Nephritis.