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The Prognosis of Membranoproliferative Glomerulonephritis (MPGN)

2013-02-05 11:16

Prognosis of Membranoproliferative GlomerulonephritisWith the characteristics of mesangial cell proliferation and structural changes in glomerular capillary walls, Membranoproliferative Glomerulonephritis (MPGN) is divided into three types: I, II and III. Different types have various prognosis of Membranoproliferative Glomerulonephritis (MPGN). Here, we will respectively introduce the prognosis of these three types according to their characteristics.

The prognosis of Type I MPGN

With the immune complexes depositing in the glomerular capillary endothelium, the diffuse thickening and duplication of glomerular basement membrane will occur. Besides, Type 1 MPGN usually companies with chronic or progressive renal insufficiency. In the early stage, patients’ condition develops very slowly, but the speed of condition deteriorating will increase after 5 years. 5%~20% of patients with Type 1 MPGN can be remitted, while most ones will develop renal failure finally. High blood pressure, kidney function decrease, crescents formation, Nephrotic Syndrome, etc, all can worse the prognosis of Membranoproliferative Glomerulonephritis.

The prognosis of Type II MPGN

The glomerular changes in Type II are quite different from Type I. As a lot of immune complexes build up in the glomerular basement membrane, the change presents glomerular basement membrane diffuse thickening. Therefore, Type II MPGN is also called dense deposit disease (DDD). The prognosis of Type II MPGN is worse when patients have high blood pressure, anemia, more than 20% crescents formation and Nephrotic Syndrome, while the prognosis will be relatively better.

The prognosis of Type III MPGN

The pathogenesis of Type III MPGN, which usually has abnormal complement system, is very similar to the one of Type I MPGN. The prognosis of this type MPGN is not very good, but better than Type I MPGN and DDD. The recurrence rate of kidney transplant in this stage is 80%~90%.

Since prognosis of Membranoproliferative Glomerulonephritis including Type I, Type II and Type III, is not very well, patients should take correct treatment timely. Any follow-up questions can be asked, through consulting online or writing down the form below.

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Tag: Nephritis

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