Stem Cells2013-10-15 14:35
1. What are Stem Cells?
Stem cells is a kind of self-renewing cells, which are immature and do not fully differentiate, and have the potential function of regenerating all kinds of tissues and organs. So they are called "universal cells".
According to the different original sources, stem cells can be divided into embryonic stem cells, somatic stem cells, hematopoietic stem cells, neural stem cells and muscle stem cells etc. According to the development potential, stem cells can be divided into totipotent stem cells, pluripotent stem cells and unipotent stem cells.
2. The Characteristics and Advantages of Stem Cells
a. Stem cells have the strong abilities of proliferation and multi-direction differentiation, so a lot of descendants are generated.
b. Through intercellular interactions and generating cell factors to inhibit the proliferation and immune reaction of T cells, thus rebuilding the immune function.
c. Stem cells are widely available, which are easy to separate, culture, proliferate and purify, daughter cells still remain the same characteristics as mother cells after proliferating many times.
d. Low immunogenicity. Stem cells don’t have the character of immunological rejection and the problem of blood matching because stem cells are in the initial state and can not be identified easily.
e. Stem cells have the unique ability of ‘homing’. Through the function of ‘homing’, the traumatic signal can stimulate stem cells to differentiate new cells to replace the damaged organs and tissues so as to repair and rebuild the damaged cells.
3. Overview of Stem Cells Therapy
Stem Cells Therapy is an advanced medical technology, which brings new hope for the treatment of incurable diseases. It has a wide curative range such as Kidney Diseases, Diabetes, Heart Disease, Leukaemia, etc. With this therapy, healthy cells enter human body through intravenous injections for achieving the purpose of repairing and changing the damaged cells and tissues.
The procedure of Stem Cells Therapy: We should first collect the stem cells, then, cultivate the stem cells in the laboratory. The cultivation needs about seven days. When the stem cells grow the best, they will be infused into the patients’ body through veins.
Characteristics of this treatment include: wide curative range; the best carrier of immunization and gene therapy; safety, low-toxicity or non-toxicity and no immune rejection; adequate therapy materials, unlimited collection and cultivation of stem cells.
4. Possible Side-Effects and Complications of Stem Cells Therapy
Stem Cells Therapy is an advanced technology with the character of safety, no-toxin or low-toxin, and no side-effect. The common clinical response is anaphylaxis which will disappear in several hours by itself. Patients don’t need to worry when temperature is up to 39°, take little hormone when temperature is more than 39°. In addition, patients will have better sleep and spirit after receiving Stem Cells Therapy, and this is the early effective effect.
5. The Indications and Contraindications of Stem Cells Therapy
I. Primary kidney diseases such as Primary Nephrotic Syndrome, Acute Glomerulonephritis, Accelerated Glomerulonephritis, Chronic Glomerulonephritis, IgA Nephropathy, Mesangial Proliferative Glomerulonephritis, Membranous Nephropathy, FSGS, Membrane Proliferative Glomerulonephritis and agnogenic glomerulosclerosis.
II. Renal injury caused due to autoimmune diseases and connective tissue disease: Lupus Nephritis, Anaphylactic Purpura Nephritis, Glomerular Basement Membrane Disease, Primary Renal Vasculitis, Chronic Infectious Arthritis, Ankylosing Spondylitis, Psoriasis, Sicca Syndrome, Scleroderma, Polymyositis, Dermatomyositis, Behcet's Disease, etc.
III. Renal injury caused by metabolic diseases: Diabetic Nephropathy, Hyperuricemic Nephropaihy and hypokalemic nephropathy.
IV. Renal tubular disease and renal interstitial disease: Renal Tubular Acidosis, various kinds of acute and chronic interstitial nephritis.
V. Renal injury caused by infectious diseases: hepatitis B Virus associated glomerulonephritis, hepatitis C virus associated glomerulonephritis.
VI. III cardiac function and IV.
VII. Cardiorenal Syndrome and Hepatorenal Syndrome.
VIII. Renal Injury caused by hypertension.
IX. Hereditary kidney diseases: Alport nephritis, thin glomerular basement membrane disease, fabry disease, etc.
I. Patients who are allergic to stem cells or those with serious allergy.
II. Pregnant women (woman in lactation period is allowed).
III. Infected patients who is still out of control.
IV. Serious mental illness patient, including patient with tristimania.
V. Severe hypertension (BP>160/100mmHg).
VI. Patient with III and IV cardiac function, coronary disease, unstable angina, myocardial ischemia.
VII. Patients with obvious renal atrophy.
VIII. patients with severe bleeding tendency.
IX. Patients who are taking part in clinical research.
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